Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain.
Identifieur interne : 000393 ( Main/Exploration ); précédent : 000392; suivant : 000394Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain.
Auteurs : Teresa Del Rosal [Espagne] ; Fernando Baquero-Artigao ; Cristina Calvo ; María J. Mellado ; Juan C. Molina ; María Del Mar Santos ; María J. Cilleruelo ; Mercedes Bueno ; Pilar Storch De Gracia ; Covadonga Terol ; Miguel Roa ; Roi Pi Eiro ; Milagros García L Pez-Hortelano ; María L. García-García ; Sonia Rodríguez ; María Penín ; Alejandro Zarauza ; Francisco Alvarado ; Ana De Blas ; Enrique Otheo ; Alfonso Rodríguez ; María L. Herreros ; Alfredo Tagarro ; Luis Grande ; José T. Ramos ; Irene Maté ; Cristina Mu Oz ; Miguel Zafra ; María P. Romero-G Mez ; Elia Pérez-Fernández ; Alberto Delgado ; Inmaculada Casas ; María E. CabezasSource :
- Influenza and other respiratory viruses [ 1750-2659 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (complications), Grippe humaine (virologie), Grippe humaine (épidémiologie), Hospitalisation (statistiques et données numériques), Humains (MeSH), Mâle (MeSH), Nourrisson (MeSH), Pandémies (MeSH), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sous-type H1N1 du virus de la grippe A (physiologie), Unités de soins intensifs pédiatriques (statistiques et données numériques), Études rétrospectives (MeSH).
- MESH :
- génétique : Sous-type H1N1 du virus de la grippe A.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- physiologie : Sous-type H1N1 du virus de la grippe A.
- statistiques et données numériques : Hospitalisation, Unités de soins intensifs pédiatriques.
- virologie : Grippe humaine.
- épidémiologie : Espagne, Grippe humaine.
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Nourrisson, Pandémies, Études rétrospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adolescent (MeSH), Child (MeSH), Child, Preschool (MeSH), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Infant (MeSH), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza A Virus, H1N1 Subtype (physiology), Influenza, Human (complications), Influenza, Human (epidemiology), Influenza, Human (virology), Intensive Care Units, Pediatric (statistics & numerical data), Male (MeSH), Pandemics (MeSH), Retrospective Studies (MeSH), Spain (epidemiology).
- MESH :
- geographic , epidemiology : Spain.
- complications : Influenza, Human.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- physiology : Influenza A Virus, H1N1 Subtype.
- statistics & numerical data : Hospitalization, Intensive Care Units, Pediatric.
- virology : Influenza, Human.
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Male, Pandemics, Retrospective Studies.
Abstract
OBJECTIVE
To describe the epidemiological and clinical characteristics of children hospitalized with 2009 pandemic influenza (pH1N1) in Madrid, Spain.
PATIENTS/METHODS
We included patients less than 14 years of age admitted to one of 18 hospitals in Madrid, Spain, between May 1 and November 30, 2009 and diagnosed with pH1N1 by polymerase chain reaction. A retrospective chart review was conducted and data were compared by age, presence of high-risk medical conditions, and pediatric intensive care unit (PICU) admission.
RESULTS
A total of 517 pH1N1 cases were included for final analysis. One hundred and forty-two patients (27·5%) had predisposing underlying illnesses, with immunosuppression (36 children, 7%) and moderate persistent asthma (34, 6·6%) being the most common ones. Patients with underlying medical conditions had longer hospital stays [median 5, interquartile range (IQR) 3-8 days, versus median 4, IQR 3-6, P < 0·001] and required intensive care (20·4% versus 5·9%, P < 0·001) and mechanical ventilation more frequently than previously healthy children. Globally, intensive care was required for 51 patients (10%) and invasive mechanical ventilation for 12 (2%). Pediatric intensive care unit admission was significantly associated with abnormal initial chest X-ray [Odds Ratio (OR) 3·5, 95% confidence interval (CI) 1·5-8·5], underlying neurological condition (OR 3·1, CI 1·2-7·5) and immunosuppression (OR 2·9, 1·2-6·8). Five patients (0·9%) died; two with severe neurological disease, two with leukemia, and one with a malignant solid tumor.
CONCLUSIONS
Children with underlying medical conditions experienced more severe pH1N1 disease. Risk factors for admission to the PICU included underlying neurological conditions, immunosuppression and abnormal initial chest X-ray.
DOI: 10.1111/j.1750-2659.2011.00272.x
PubMed: 21781285
PubMed Central: PMC5780672
Affiliations:
Links toward previous steps (curation, corpus...)
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Cabezas</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21781285</idno><idno type="pmid">21781285</idno><idno type="doi">10.1111/j.1750-2659.2011.00272.x</idno><idno type="pmc">PMC5780672</idno><idno type="wicri:Area/Main/Corpus">00353</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00353</idno><idno type="wicri:Area/Main/Curation">000353</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000353</idno><idno type="wicri:Area/Main/Exploration">000353</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain.</title><author><name sortKey="Del Rosal, Teresa" sort="Del Rosal, Teresa" uniqKey="Del Rosal T" first="Teresa" last="Del Rosal">Teresa Del Rosal</name><affiliation wicri:level="3"><nlm:affiliation>Pediatrics Department, Hospital Infanta Elena, Valdemoro, Madrid, Spain. teredelrosal@yahoo.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatrics Department, Hospital Infanta Elena, Valdemoro, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Baquero Artigao, Fernando" sort="Baquero Artigao, Fernando" uniqKey="Baquero Artigao F" first="Fernando" last="Baquero-Artigao">Fernando Baquero-Artigao</name></author><author><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name></author><author><name sortKey="Mellado, Maria J" sort="Mellado, Maria J" uniqKey="Mellado M" first="María J" last="Mellado">María J. Mellado</name></author><author><name sortKey="Molina, Juan C" sort="Molina, Juan C" uniqKey="Molina J" first="Juan C" last="Molina">Juan C. Molina</name></author><author><name sortKey="Santos, Maria Del Mar" sort="Santos, Maria Del Mar" uniqKey="Santos M" first="María Del Mar" last="Santos">María Del Mar Santos</name></author><author><name sortKey="Cilleruelo, Maria J" sort="Cilleruelo, Maria J" uniqKey="Cilleruelo M" first="María J" last="Cilleruelo">María J. Cilleruelo</name></author><author><name sortKey="Bueno, Mercedes" sort="Bueno, Mercedes" uniqKey="Bueno M" first="Mercedes" last="Bueno">Mercedes Bueno</name></author><author><name sortKey="Storch De Gracia, Pilar" sort="Storch De Gracia, Pilar" uniqKey="Storch De Gracia P" first="Pilar" last="Storch De Gracia">Pilar Storch De Gracia</name></author><author><name sortKey="Terol, Covadonga" sort="Terol, Covadonga" uniqKey="Terol C" first="Covadonga" last="Terol">Covadonga Terol</name></author><author><name sortKey="Roa, Miguel" sort="Roa, Miguel" uniqKey="Roa M" first="Miguel" last="Roa">Miguel Roa</name></author><author><name sortKey="Pi Eiro, Roi" sort="Pi Eiro, Roi" uniqKey="Pi Eiro R" first="Roi" last="Pi Eiro">Roi Pi Eiro</name></author><author><name sortKey="Garcia L Pez Hortelano, Milagros" sort="Garcia L Pez Hortelano, Milagros" uniqKey="Garcia L Pez Hortelano M" first="Milagros" last="García L Pez-Hortelano">Milagros García L Pez-Hortelano</name></author><author><name sortKey="Garcia Garcia, Maria L" sort="Garcia Garcia, Maria L" uniqKey="Garcia Garcia M" first="María L" last="García-García">María L. García-García</name></author><author><name sortKey="Rodriguez, Sonia" sort="Rodriguez, Sonia" uniqKey="Rodriguez S" first="Sonia" last="Rodríguez">Sonia Rodríguez</name></author><author><name sortKey="Penin, Maria" sort="Penin, Maria" uniqKey="Penin M" first="María" last="Penín">María Penín</name></author><author><name sortKey="Zarauza, Alejandro" sort="Zarauza, Alejandro" uniqKey="Zarauza A" first="Alejandro" last="Zarauza">Alejandro Zarauza</name></author><author><name sortKey="Alvarado, Francisco" sort="Alvarado, Francisco" uniqKey="Alvarado F" first="Francisco" last="Alvarado">Francisco Alvarado</name></author><author><name sortKey="De Blas, Ana" sort="De Blas, Ana" uniqKey="De Blas A" first="Ana" last="De Blas">Ana De Blas</name></author><author><name sortKey="Otheo, Enrique" sort="Otheo, Enrique" uniqKey="Otheo E" first="Enrique" last="Otheo">Enrique Otheo</name></author><author><name sortKey="Rodriguez, Alfonso" sort="Rodriguez, Alfonso" uniqKey="Rodriguez A" first="Alfonso" last="Rodríguez">Alfonso Rodríguez</name></author><author><name sortKey="Herreros, Maria L" sort="Herreros, Maria L" uniqKey="Herreros M" first="María L" last="Herreros">María L. Herreros</name></author><author><name sortKey="Tagarro, Alfredo" sort="Tagarro, Alfredo" uniqKey="Tagarro A" first="Alfredo" last="Tagarro">Alfredo Tagarro</name></author><author><name sortKey="Grande, Luis" sort="Grande, Luis" uniqKey="Grande L" first="Luis" last="Grande">Luis Grande</name></author><author><name sortKey="Ramos, Jose T" sort="Ramos, Jose T" uniqKey="Ramos J" first="José T" last="Ramos">José T. Ramos</name></author><author><name sortKey="Mate, Irene" sort="Mate, Irene" uniqKey="Mate I" first="Irene" last="Maté">Irene Maté</name></author><author><name sortKey="Mu Oz, Cristina" sort="Mu Oz, Cristina" uniqKey="Mu Oz C" first="Cristina" last="Mu Oz">Cristina Mu Oz</name></author><author><name sortKey="Zafra, Miguel" sort="Zafra, Miguel" uniqKey="Zafra M" first="Miguel" last="Zafra">Miguel Zafra</name></author><author><name sortKey="Romero G Mez, Maria P" sort="Romero G Mez, Maria P" uniqKey="Romero G Mez M" first="María P" last="Romero-G Mez">María P. Romero-G Mez</name></author><author><name sortKey="Perez Fernandez, Elia" sort="Perez Fernandez, Elia" uniqKey="Perez Fernandez E" first="Elia" last="Pérez-Fernández">Elia Pérez-Fernández</name></author><author><name sortKey="Delgado, Alberto" sort="Delgado, Alberto" uniqKey="Delgado A" first="Alberto" last="Delgado">Alberto Delgado</name></author><author><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name></author><author><name sortKey="Cabezas, Maria E" sort="Cabezas, Maria E" uniqKey="Cabezas M" first="María E" last="Cabezas">María E. Cabezas</name></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Female (MeSH)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza A Virus, H1N1 Subtype (physiology)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Intensive Care Units, Pediatric (statistics & numerical data)</term><term>Male (MeSH)</term><term>Pandemics (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Grippe humaine (complications)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Pandémies (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Sous-type H1N1 du virus de la grippe A (physiologie)</term><term>Unités de soins intensifs pédiatriques (statistiques et données numériques)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term><term>Intensive Care Units, Pediatric</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term><term>Unités de soins intensifs pédiatriques</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Pandemics</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Pandémies</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To describe the epidemiological and clinical characteristics of children hospitalized with 2009 pandemic influenza (pH1N1) in Madrid, Spain.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS/METHODS</b></p><p>We included patients less than 14 years of age admitted to one of 18 hospitals in Madrid, Spain, between May 1 and November 30, 2009 and diagnosed with pH1N1 by polymerase chain reaction. A retrospective chart review was conducted and data were compared by age, presence of high-risk medical conditions, and pediatric intensive care unit (PICU) admission.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 517 pH1N1 cases were included for final analysis. One hundred and forty-two patients (27·5%) had predisposing underlying illnesses, with immunosuppression (36 children, 7%) and moderate persistent asthma (34, 6·6%) being the most common ones. Patients with underlying medical conditions had longer hospital stays [median 5, interquartile range (IQR) 3-8 days, versus median 4, IQR 3-6, P < 0·001] and required intensive care (20·4% versus 5·9%, P < 0·001) and mechanical ventilation more frequently than previously healthy children. Globally, intensive care was required for 51 patients (10%) and invasive mechanical ventilation for 12 (2%). Pediatric intensive care unit admission was significantly associated with abnormal initial chest X-ray [Odds Ratio (OR) 3·5, 95% confidence interval (CI) 1·5-8·5], underlying neurological condition (OR 3·1, CI 1·2-7·5) and immunosuppression (OR 2·9, 1·2-6·8). Five patients (0·9%) died; two with severe neurological disease, two with leukemia, and one with a malignant solid tumor.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Children with underlying medical conditions experienced more severe pH1N1 disease. Risk factors for admission to the PICU included underlying neurological conditions, immunosuppression and abnormal initial chest X-ray.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21781285</PMID><DateCompleted><Year>2012</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-2659</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>6</Issue><PubDate><Year>2011</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Influenza and other respiratory viruses</Title><ISOAbbreviation>Influenza Other Respir Viruses</ISOAbbreviation></Journal><ArticleTitle>Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain.</ArticleTitle><Pagination><MedlinePgn>e544-51</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1750-2659.2011.00272.x</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To describe the epidemiological and clinical characteristics of children hospitalized with 2009 pandemic influenza (pH1N1) in Madrid, Spain.</AbstractText><AbstractText Label="PATIENTS/METHODS" NlmCategory="METHODS">We included patients less than 14 years of age admitted to one of 18 hospitals in Madrid, Spain, between May 1 and November 30, 2009 and diagnosed with pH1N1 by polymerase chain reaction. A retrospective chart review was conducted and data were compared by age, presence of high-risk medical conditions, and pediatric intensive care unit (PICU) admission.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 517 pH1N1 cases were included for final analysis. One hundred and forty-two patients (27·5%) had predisposing underlying illnesses, with immunosuppression (36 children, 7%) and moderate persistent asthma (34, 6·6%) being the most common ones. Patients with underlying medical conditions had longer hospital stays [median 5, interquartile range (IQR) 3-8 days, versus median 4, IQR 3-6, P < 0·001] and required intensive care (20·4% versus 5·9%, P < 0·001) and mechanical ventilation more frequently than previously healthy children. Globally, intensive care was required for 51 patients (10%) and invasive mechanical ventilation for 12 (2%). Pediatric intensive care unit admission was significantly associated with abnormal initial chest X-ray [Odds Ratio (OR) 3·5, 95% confidence interval (CI) 1·5-8·5], underlying neurological condition (OR 3·1, CI 1·2-7·5) and immunosuppression (OR 2·9, 1·2-6·8). Five patients (0·9%) died; two with severe neurological disease, two with leukemia, and one with a malignant solid tumor.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Children with underlying medical conditions experienced more severe pH1N1 disease. Risk factors for admission to the PICU included underlying neurological conditions, immunosuppression and abnormal initial chest X-ray.</AbstractText><CopyrightInformation>© 2011 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>del Rosal</LastName><ForeName>Teresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Pediatrics Department, Hospital Infanta Elena, Valdemoro, Madrid, Spain. teredelrosal@yahoo.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baquero-Artigao</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Mellado</LastName><ForeName>María J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Molina</LastName><ForeName>Juan C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Santos</LastName><ForeName>María del Mar</ForeName><Initials>Mdel M</Initials></Author><Author ValidYN="Y"><LastName>Cilleruelo</LastName><ForeName>María J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Bueno</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Storch de Gracia</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Terol</LastName><ForeName>Covadonga</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Roa</LastName><ForeName>Miguel Á</ForeName><Initials>MÁ</Initials></Author><Author ValidYN="Y"><LastName>Piñeiro</LastName><ForeName>Roi</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>García López-Hortelano</LastName><ForeName>Milagros</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>García-García</LastName><ForeName>María L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Sonia</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Penín</LastName><ForeName>María</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Zarauza</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Alvarado</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>de Blas</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Otheo</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Herreros</LastName><ForeName>María L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Tagarro</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Grande</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Ramos</LastName><ForeName>José T</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Maté</LastName><ForeName>Irene</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Muñoz</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Zafra</LastName><ForeName>Miguel Á</ForeName><Initials>MÁ</Initials></Author><Author ValidYN="Y"><LastName>Romero-Gómez</LastName><ForeName>María P</ForeName><Initials>MP</Initials></Author><Author ValidYN="Y"><LastName>Pérez-Fernández</LastName><ForeName>Elia</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Delgado</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Cabezas</LastName><ForeName>María E</ForeName><Initials>ME</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>07</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Influenza Other Respir Viruses</MedlineTA><NlmUniqueID>101304007</NlmUniqueID><ISSNLinking>1750-2640</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015278" MajorTopicYN="N">Intensive Care Units, Pediatric</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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IdType="pubmed">21041594</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Alvarado, Francisco" sort="Alvarado, Francisco" uniqKey="Alvarado F" first="Francisco" last="Alvarado">Francisco Alvarado</name><name sortKey="Baquero Artigao, Fernando" sort="Baquero Artigao, Fernando" uniqKey="Baquero Artigao F" first="Fernando" last="Baquero-Artigao">Fernando Baquero-Artigao</name><name sortKey="Bueno, Mercedes" sort="Bueno, Mercedes" uniqKey="Bueno M" first="Mercedes" last="Bueno">Mercedes Bueno</name><name sortKey="Cabezas, Maria E" sort="Cabezas, Maria E" uniqKey="Cabezas M" first="María E" last="Cabezas">María E. Cabezas</name><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name><name sortKey="Cilleruelo, Maria J" sort="Cilleruelo, Maria J" uniqKey="Cilleruelo M" first="María J" last="Cilleruelo">María J. Cilleruelo</name><name sortKey="De Blas, Ana" sort="De Blas, Ana" uniqKey="De Blas A" first="Ana" last="De Blas">Ana De Blas</name><name sortKey="Delgado, Alberto" sort="Delgado, Alberto" uniqKey="Delgado A" first="Alberto" last="Delgado">Alberto Delgado</name><name sortKey="Garcia Garcia, Maria L" sort="Garcia Garcia, Maria L" uniqKey="Garcia Garcia M" first="María L" last="García-García">María L. García-García</name><name sortKey="Garcia L Pez Hortelano, Milagros" sort="Garcia L Pez Hortelano, Milagros" uniqKey="Garcia L Pez Hortelano M" first="Milagros" last="García L Pez-Hortelano">Milagros García L Pez-Hortelano</name><name sortKey="Grande, Luis" sort="Grande, Luis" uniqKey="Grande L" first="Luis" last="Grande">Luis Grande</name><name sortKey="Herreros, Maria L" sort="Herreros, Maria L" uniqKey="Herreros M" first="María L" last="Herreros">María L. Herreros</name><name sortKey="Mate, Irene" sort="Mate, Irene" uniqKey="Mate I" first="Irene" last="Maté">Irene Maté</name><name sortKey="Mellado, Maria J" sort="Mellado, Maria J" uniqKey="Mellado M" first="María J" last="Mellado">María J. Mellado</name><name sortKey="Molina, Juan C" sort="Molina, Juan C" uniqKey="Molina J" first="Juan C" last="Molina">Juan C. Molina</name><name sortKey="Mu Oz, Cristina" sort="Mu Oz, Cristina" uniqKey="Mu Oz C" first="Cristina" last="Mu Oz">Cristina Mu Oz</name><name sortKey="Otheo, Enrique" sort="Otheo, Enrique" uniqKey="Otheo E" first="Enrique" last="Otheo">Enrique Otheo</name><name sortKey="Penin, Maria" sort="Penin, Maria" uniqKey="Penin M" first="María" last="Penín">María Penín</name><name sortKey="Perez Fernandez, Elia" sort="Perez Fernandez, Elia" uniqKey="Perez Fernandez E" first="Elia" last="Pérez-Fernández">Elia Pérez-Fernández</name><name sortKey="Pi Eiro, Roi" sort="Pi Eiro, Roi" uniqKey="Pi Eiro R" first="Roi" last="Pi Eiro">Roi Pi Eiro</name><name sortKey="Ramos, Jose T" sort="Ramos, Jose T" uniqKey="Ramos J" first="José T" last="Ramos">José T. Ramos</name><name sortKey="Roa, Miguel" sort="Roa, Miguel" uniqKey="Roa M" first="Miguel" last="Roa">Miguel Roa</name><name sortKey="Rodriguez, Alfonso" sort="Rodriguez, Alfonso" uniqKey="Rodriguez A" first="Alfonso" last="Rodríguez">Alfonso Rodríguez</name><name sortKey="Rodriguez, Sonia" sort="Rodriguez, Sonia" uniqKey="Rodriguez S" first="Sonia" last="Rodríguez">Sonia Rodríguez</name><name sortKey="Romero G Mez, Maria P" sort="Romero G Mez, Maria P" uniqKey="Romero G Mez M" first="María P" last="Romero-G Mez">María P. Romero-G Mez</name><name sortKey="Santos, Maria Del Mar" sort="Santos, Maria Del Mar" uniqKey="Santos M" first="María Del Mar" last="Santos">María Del Mar Santos</name><name sortKey="Storch De Gracia, Pilar" sort="Storch De Gracia, Pilar" uniqKey="Storch De Gracia P" first="Pilar" last="Storch De Gracia">Pilar Storch De Gracia</name><name sortKey="Tagarro, Alfredo" sort="Tagarro, Alfredo" uniqKey="Tagarro A" first="Alfredo" last="Tagarro">Alfredo Tagarro</name><name sortKey="Terol, Covadonga" sort="Terol, Covadonga" uniqKey="Terol C" first="Covadonga" last="Terol">Covadonga Terol</name><name sortKey="Zafra, Miguel" sort="Zafra, Miguel" uniqKey="Zafra M" first="Miguel" last="Zafra">Miguel Zafra</name><name sortKey="Zarauza, Alejandro" sort="Zarauza, Alejandro" uniqKey="Zarauza A" first="Alejandro" last="Zarauza">Alejandro Zarauza</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Del Rosal, Teresa" sort="Del Rosal, Teresa" uniqKey="Del Rosal T" first="Teresa" last="Del Rosal">Teresa Del Rosal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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